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High tissue inhibitor of metalloproteinases (timp 1) levels may promote prostate cancer invasiveness

High TIMP 1 levels have been associated with poor prognosis in studies of breast and colon cancer. Now, researchers from Lousiana have established that high levels in prostate cancer were associated with a poor prognosis. These workers found that high levels occurred particularly in Black people, which correlates with the observation of increased aggressive behaviour in this population. Whilst TIMP 1 usually inhibits metalloproteinase and thereby inhibits tumour growth, it now seems that an overproduction of TIMP 1 fails to keep the ennzyme/metalloproteinase in check and tumour growth is promoted.